Synthesis of Hybrid Cyclopeptides through Enzymatic Macrocyclization
نویسندگان
چکیده
منابع مشابه
Synthesis of Hybrid Cyclopeptides through Enzymatic Macrocyclization
Natural products comprise a diverse array of molecules, many of which are biologically active. Most natural products are derived from combinations of polyketides, peptides, sugars, and fatty-acid building blocks. Peptidic macrocycles have attracted attention as potential therapeutics possessing cell permeability, stability, and easy-to-control variability. Here, we show that enzymes from the pa...
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The macrocyclization of linear peptides is very often accompanied by significant improvements in their stability and biological activity. Many strategies are available for their chemical macrocyclization, however, enzyme-mediated methods remain of great interest in terms of synthetic utility. To date, known macrocyclization enzymes have been shown to be active on both peptide and protein substr...
متن کاملGraphical Abstract Preparation of penta-azole containing cyclopeptides: challenges in macrocyclization
Herein is described the synthesis of several analogs of the natural product IB-01211 from concatenated azoles, via a biomimetic pathway based on cyclization-oxidation of serine containing peptides combined with the Hantzsch synthesis. The macrocyclization of rigid peptide compounds 1 and 2 to give IB-01211 and its epimer 12b was explored, and the results are compared here to those previously ob...
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A method for the decarboxylative macrocyclization of peptides bearing N-terminal Michael acceptors has been developed. This synthetic method enables the efficient synthesis of cyclic peptides containing γ-amino acids and is tolerant of functionalities present in both natural and non-proteinogenic amino acids. Linear precursors ranging from 3 to 15 amino acids cyclize effectively under this phot...
متن کاملSynthesis of cyclopeptides from plants, fungi and sea animals*
A very flexible synthesis of non proteinogenic amino acids and an effective ring closure method for formation of macrolactams were elaborated. These methods are prerequisite for economical synthesis of cyclopeptides . The total syntheses of several cyclopeptides which had been isolated from plants, fungi and lower sea animals are described.
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ژورنال
عنوان ژورنال: ChemistryOpen
سال: 2016
ISSN: 2191-1363
DOI: 10.1002/open.201600134